Article
Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy.
Virology - 5 Jul 2011
Joshi Anjali, Garg Himanshu, Ablan Sherimay, Freed Eric O, Nagashima Kunio, Manjunath N, Shankar Premlata
Abstract excerpt
Targeting the HIV entry and assembly pathways holds promise for development of novel anti-HIV gene therapy vectors. We characterized discrete dominant negative (DN) Gag and Envelope mutants for their anti-HIV-1 activity. We show here that capsid mutants (Q155N and Y164A) are more potent inhibitors of WT HIV than the matrix mutant 1GA. Both the Envelope mutants tested, V513E and R515A, were equally effective and a...
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