Article
A genetic polymorphism in the CYP19A1 gene and the risk of hypertension among midlife women.
Maturitas - 1 Jan 2012
Ziv-Gal Ayelet, Gallicchio Lisa, Miller Susan R, Zacur Howard A, Flaws Jodi A
Abstract excerpt
OBJECTIVE: To test whether a synonymous single nucleotide polymorphism (A→G; rs700518) in the CYP19A1 gene, which encodes the enzyme aromatase, is associated with an increased risk for hypertension of midlife women. METHODS: In a cross-sectional study, 639 midlife women were recruited. Eligible women had their blood pressure, weight and height measured, and donated a blood sample for hormone and genetic analyses....
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