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Article

The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.

BioMed research international - 1 Jan 2014

Liang Shuang, Zhou Yuanpeng, Wang Huijun, Qian Yanyan, Ma Duan, Tian Weidong, Persaud-Sharma Vishwani, Yu Chen, Ren Yunyun, Zhou Shufeng, Li Xiaotian

Abstract excerpt

OBJECTIVE: To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism. METHODS: Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were measured. Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to...

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Source

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Identifiers

PMID: 24524080
DOI: 10.1155/2014/560183
PMCID: PMC3913508

Genes

MTHFR
BHMT
CBS
RFC1
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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