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Article

Evolutionary conservation in noncoding genomic regions.

Trends in genetics : TIG - 1 Oct 2021

Leypold Nicole A, Speicher Michael R

Abstract excerpt

Humans may share more genomic commonalities with other species than previously thought. According to current estimates, ~5% of the human genome is functionally constrained, which is a much larger fraction than the ~1.5% occupied by annotated protein-coding genes. Hence, ~3.5% of the human genome comprises likely functional conserved noncoding elements (CNEs) preserved among organisms, whose common ancestors...

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PMID: 34238591
DOI: 10.1016/j.tig.2021.06.007

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