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Article

Loose ends: almost one in five human genes still have unresolved coding status.

Nucleic acids research - 21 Aug 2018

Abascal Federico, Juan David, Jungreis Irwin, Kellis Manolis, Martinez Laura, Rigau Maria, Rodriguez Jose Manuel, Vazquez Jesus, Tress Michael L

Abstract excerpt

Seventeen years after the sequencing of the human genome, the human proteome is still under revision. One in eight of the 22 210 coding genes listed by the Ensembl/GENCODE, RefSeq and UniProtKB reference databases are annotated differently across the three sets. We have carried out an in-depth investigation on the 2764 genes classified as coding by one or more sets of manual curators and not coding by others....

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Identifiers

PMID: 29982784
DOI: 10.1093/nar/gky587
PMCID: PMC6101605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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