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Article

Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.

Psychopharmacology - 1 Dec 2004

Zhu Guanshan, Lipsky Robert H, Xu Ke, Ali Sameer, Hyde Thomas, Kleinman Joel, Akhtar Longina A, Mash Deborah C, Goldman David

Abstract excerpt

RATIONALE: A common polymorphism, Val158Met, alters catechol- O-methyltransferase (COMT) enzyme activity and has been linked to psychiatric phenotypes. Bray et al. (2003) reported that COMT is subject to differential allele expression in brain, finding modest (13-22%) underexpression of a haplotype containing Val158. However, disparate findings by another group who used the same method, but in lymphoblasts, raise...

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Source

Identifiers

PMID: 15290009
DOI: 10.1007/s00213-004-1938-z

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.PMID 15290009Read ↗

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