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Article

Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2012

Biancotto Angélique, Dagur Pradeep K, Fuchs John C, Wiestner Adrian, Bagwell C Bruce, McCoy J Philip

Abstract excerpt

Increased numbers of T regulatory (T(reg)) cells are found in B-chronic lymphocytic leukemia, but the nature and function of these T(regs) remains unclear. Detailed characterization of the T(regs) in chronic lymphocytic leukemia has not been performed and the degree of heterogeneity of among these cells has not been studied to date. Using 15-color flow cytometry we show that T(reg) cells, defined using CD4, CD25,...

Topics

Adult
Cell Separation
Female
Flow Cytometry
Humans
Immunophenotyping
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Phenotype
T-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 22101351
DOI: 10.1038/modpathol.2011.164
PMCID: PMC3512204

Genes

FOXP3
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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