Article
Expansion of T cells expressing low CD4 or CD8 levels in B-cell chronic lymphocytic leukemia: correlation with disease status and neoplastic phenotype.
Blood - 15 Apr 1994
Dianzani U, Omedè P, Marmont F, DiFranco D, Fusaro A, Bragardo M, Redoglia V, Giaretta F, Mairone L, Boccadoro M
Abstract excerpt
Peripheral blood (PB) T cells from 56 patients with B-cell chronic lymphocytic leukemia (B-CLL) were analyzed by two- and three-color immunofluorescence (IF) to determine the expansion of distinct T-cell subsets and their relationship with the clinical and biological features of the disease. We detected the expansion of an unusual T-cell subpopulation expressing lower CD4 or CD8 levels (CD4lo, CD8lo) than classic...
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