Article
Lack of association between essential hypertension and GSTO1 uncommon genetic variants in Italian patients.
Genetic testing and molecular biomarkers - 1 Jun 2012
Polimanti Renato, Piacentini Sara, Lazzarin Natalia, Re Maria Antonietta, Manfellotto Dario, Fuciarelli Maria
Abstract excerpt
BACKGROUND AND OBJECTIVE: Essential hypertension (EH) is a complex phenotype that is affected by multiple genetic and environmental factors. Some authors have explored the role of genetic variability of the glutathione S-transferase (GST) enzymes in EH risk with contrasting results. In particular, our previous study investigated two GSTO common polymorphisms, but we did not find a significant outcome. The aim of...
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