Article
Genetic variants in TGFβ-1 and PAI-1 as possible risk factors for cardiovascular disease after radiotherapy for breast cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jan 2012
Hilbers Florentine S M, Boekel Naomi B, van den Broek Alexandra J, van Hien Richard, Cornelissen Sten, Aleman Berthe M P, van 't Veer Laura J, van Leeuwen Flora E, Schmidt Marjanka K
Abstract excerpt
BACKGROUND AND PURPOSE: It has been established that radiotherapy can increase cardiovascular disease (CVD) risk. Genetic variants, which play a role in the tissue, damage response and angiogenesis regulating TGFβ pathway might give us insight into the mechanisms underlying radiation-induced CVD. We examined the effects of two polymorphisms, TGFβ1 29C>T and PAI-1 5G>4G, on CVD incidence. MATERIALS AND METHODS:...
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