Article
Malnutrition Risk in Kidney Recipients Treated With Mycophenolate Mofetil Is Associated With IMPDH1 rs2278294 Polymorphism.
Transplantation proceedings - 1 Jan 2000
Pazik J, Lewandowski Z, Nowacka Cieciura E, Ołdak M, Podgórska M, Sadowska A, Dęborska Materkowska D, Durlik M
Abstract excerpt
BACKGROUND: Malnutrition is known to increase morbidity and mortality in renal transplant recipients, whereas little is known about genetic predisposition to low body mass index (BMI) in the transplant setting. Inosine monophosphate dehydrogenase (IMPDH) regulates intracellular fat accumulation, pre-adipicytes maturation, and is a target of mycophenolic acid (MPA) used as a standard immunosuppressant. We...
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