Article
Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus.
Pharmacogenetics and genomics - 1 Dec 2013
Elens Laure, Sombogaard Ferdi, Hesselink Dennis A, van Schaik Ron H N, van Gelder Teun
Abstract excerpt
BACKGROUND: New-onset diabetes after transplantation (NODAT) is an important complication after kidney transplantation. The etiology of the malady is multifactorial and includes both environmental and genetic factors. NODAT is a polygenic disease and many single-nucleotide polymorphisms could constitute potential risk factors. Peroxisome proliferator-activated receptor α (PPARα) and P450 oxidoreductase (POR) play...
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