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[SNP rs16917496 within SET8 3'UTR is associated with the age of onset of breast cancer].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Nov 2012

Zhang Bai-lin, Song Feng-ju, Zheng Hong, Zhang Li-na, Zhao Yan-rui, Chen Ke-xin

Abstract excerpt

OBJECTIVE: We have identified a SNP within the seed-binding region for miR-502 in the 3'-UTR of the SET8 gene that codes for a methyltransferase for histone H4. SET8 methylates TP53 and thus regulates cell proliferation and genome stability. This study is to investigate the role for this SNP and its interaction with the TP53 codon 72 SNP in the age of onset of breast cancer. METHODS: We conducted a case-only...

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Identifiers

PMID: 23291132
DOI: 10.3760/cma.j.issn.0253-3766.2012.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[SNP rs16917496 within SET8 3'UTR is associated with the age of onset of breast cancer].PMID 23291132Read ↗

An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset.Semantic proximity Read ↗

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A functional single nucleotide polymorphism of SET8 is prognostic for breast cancer.Semantic proximity Read ↗

Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.Semantic proximity Read ↗

Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma.Semantic proximity Read ↗

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MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.Semantic proximity Read ↗

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