Article
An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2009
Song Fengju, Zheng Hong, Liu Ben, Wei Sheng, Dai Hongji, Zhang Lina, Calin George A, Hao Xishan, Wei Qingyi, Zhang Wei, Chen Kexin
Abstract excerpt
PURPOSE: MicroRNAs regulate gene expression by binding to the 3'-untranslated region (UTR) of target genes. Single-nucleotide polymorphisms of critical genes may affect their regulation by microRNAs. We have identified a single-nucleotide polymorphism within the miR-502 seed binding region in the 3'-UTR of the SET8 gene. SET8 methylates TP53 and regulates genome stability. We investigated the role of this SET8...
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