Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

doi:10.1007/s10048-011-0305-6

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Article

Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.

Neurogenetics - 1 Feb 2012

Lill Christina M, Schjeide Brit-Maren M, Akkad Denis A, Blaschke Paul, Winkelmann Alexander, Gerdes Lisa-Ann, Hoffjan Sabine, Luessi Felix, Dörner Thomas, Li Shu-Chen, Steinhagen-Thiessen Elisabeth, Lindenberger Ulman, Chan Andrew, Hartung Hans-Peter, Aktas Orhan, Lohse Peter, Kümpfel Tania, Kubisch Christian, Epplen Joerg T, Zettl Uwe K, Bertram Lars, Zipp Frauke

Abstract excerpt

Recent genome-wide association studies have implicated the "signal transducer and activator of transcription 3" gene (STAT3) as a putative new multiple sclerosis (MS) susceptibility locus. However, independent validation studies are sparse. Therefore, we performed a genetic association study of two STAT3 polymorphisms (rs744166 and rs2293152) in a large and independent German case-control sample of 5,904...

Topics

Case-Control Studies
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Germany

Humans

Multiple Sclerosis

Polymorphism, Single Nucleotide

Risk

STAT3 Transcription Factor

Source

Open in PubMed

Identifiers

PMID: 22095036
DOI: 10.1007/s10048-011-0305-6

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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