Article
Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array.
Genetic epidemiology - 1 Dec 2015
Dankowski Theresa, Buck Dorothea, Andlauer Till F M, Antony Gisela, Bayas Antonios, Bechmann Lukas, Berthele Achim, Bettecken Thomas, Chan Andrew, Franke Andre, Gold Ralf, Graetz Christiane, Haas Jürgen, Hecker Michael, Herms Stefan, Infante-Duarte Carmen, Jöckel Karl-Heinz, Kieseier Bernd C, Knier Benjamin, Knop Matthias, Kümpfel Tania, Lichtner Peter, Lieb Wolfgang, Lill Christina M, Limmroth Volker, Linker Ralf A, Loleit Verena, Meuth Sven G, Moebus Susanne, Müller-Myhsok Bertram, Nischwitz Sandra, Nöthen Markus M, Paul Friedemann, Pütz Michael, Ruck Tobias, Salmen Anke, Stangel Martin, Stellmann Jan-Patrick, Strauch Konstantin, Stürner Klarissa H, Tackenberg Björn, Then Bergh Florian, Tumani Hayrettin, Waldenberger Melanie, Weber Frank, Wiendl Heinz, Wildemann Brigitte, Zettl Uwe K, Ziemann Ulf, Zipp Frauke, Hemmer Bernhard, Ziegler Andreas
Abstract excerpt
Genome-wide association studies (GWAS) successfully identified various chromosomal regions to be associated with multiple sclerosis (MS). The primary aim of this study was to replicate reported associations from GWAS using an exome array in a large German study. German MS cases (n = 4,476) and German controls (n = 5,714) were genotyped using the Illumina HumanExome v1-Chip. Genotype calling was performed with the...
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