Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Nov 2011

Lu Paul P Y, Ramanan Narendrakumar

Abstract excerpt

Previous studies have shown that neuron-specific deletion of serum response factor (SRF) results in deficits in tangential cell migration, guidance-dependent circuit assembly, activity-dependent gene expression, and synaptic plasticity in the hippocampus. Furthermore, SRF deletion in mouse embryonic stem cells causes cell death in vitro. However, the requirement of SRF for early neuronal development including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neocortex

Share to Nestin

Share to Neural Pathways

Share to Neurogenesis

Share to Serum Response Factor

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22090492
DOI: 10.1523/JNEUROSCI.3015-11.2011
PMCID: PMC6633287

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serum response factor is required for cortical axon growth but is dispensable for neurogenesis and neocortical lamination.PMID 22090492Read ↗

Serum response factor regulates hippocampal lamination and dendrite development and is connected with reelin signaling.Semantic proximity Read ↗

Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.Semantic proximity Read ↗

ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron developmentSemantic proximity Read ↗

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitorsSemantic proximity Read ↗

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learningSemantic proximity Read ↗

Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.Semantic proximity Read ↗

Ebf1 controls early cell differentiation in the embryonic striatum.Semantic proximity Read ↗

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelinationSemantic proximity Read ↗

The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain.Semantic proximity Read ↗

Novel genetic tools facilitate the study of cortical neuron migration.Semantic proximity Read ↗

Ena/VASP Is Required for neuritogenesis in the developing cortex.Semantic proximity Read ↗

Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.