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Article

Analysis of hematopoietic stem cell transplant engraftment: use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancy.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 2011

Lin Ming-Tseh, Tseng Li-Hui, Beierl Katie, Harada Shuko, Hafez Michael J, Eshleman James R, Gocke Christopher D

Abstract excerpt

Polymorphic short tandem repeat (STR), or microsatellite, loci have been widely used to analyze chimerism status after allogeneic hematopoietic stem cell transplantation. The presence of a patient's DNA, as identified by STR analysis, may indicate residual or recurrent malignant disease or may represent normal hematopoiesis of patient origin. The ratio of patient-derived to donor-derived alleles is used to...

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Identifiers

PMID: 22089346
DOI: 10.1097/PDM.0b013e31821dac16
PMCID: PMC3219907

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