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Article

Somatic mutations in the HLA genes of patients with hematological malignancy.

Tissue antigens - 1 May 2012

Smith A G, Fan W, Regen L, Warnock S, Sprague M, Williams R, Nisperos B, Zhao L P, Loken M R, Hansen J A, Pereira S

Abstract excerpt

Somatic mutations and genomic alterations are frequent events in the clonal evolution of hematologic malignancies. Recent studies have reported copy neutral loss of heterozygosity (LOH) for the mismatched human leukocyte antigen (HLA) haplotype in patients relapsed after haploidentical hematopoietic cell transplantation (HCT) for a hematologic malignancy. Herein, we report 15 cases of somatic mutations in the HLA...

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Share to Hematologic Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22489945
DOI: 10.1111/j.1399-0039.2012.01868.x

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