Article
Primer site polymorphisms: potential implications for bone marrow engraftment monitoring.
Genetic testing and molecular biomarkers - 1 Jun 2009
Seywerd Katerine, Allen Richard Andrew, Dunn Samuel Terence
Abstract excerpt
Assessment of chimerism after allogeneic bone marrow transplant frequently relies on PCR amplification of donor- and recipient-specific polymorphic short tandem repeats (STR) with subsequent fluorescent detection of amplicons. In vitro amplification of STR loci is often achieved through commercially available, multiplex PCR kits. While originally developed for forensic purposes, these kits are increasingly being...
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