Article
Bone marrow transplant engraftment analysis with loss of an informative allele.
The Journal of molecular diagnostics : JMD - 1 Nov 2002
Schichman Steven A, Lin Pei, Gilbrech Lori J, Gray Pamela S, Wilson Carla S, Sawyer Jeffrey R
Abstract excerpt
Short tandem repeats (STRs) are highly polymorphic DNA sequences in the human genome. STR genotype analysis is used for human identity testing and to monitor bone marrow engraftment after allogeneic transplantation. Engraftment analysis requires one or more informative STR loci that distinguish recipient from donor. The following case illustrates that chromosome loss in tumor cells during the course of disease...
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