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Article

Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck.

Molecular carcinogenesis - 1 Oct 2012

Zhou Ziyuan, Sturgis Erich M, Liu Zhensheng, Wang Li-E, Wei Qingyi, Li Guojun

Abstract excerpt

P53 up-regulated modulator of apoptosis (PUMA) is a critical factor in the intrinsic apoptotic pathway. Through PUMA-dependent mechanisms, human papillomavirus 16 (HPV16) oncoprotein may affect apoptosis by E6-mediated p53 degradation. To examine whether the PUMA variants modify the association between HPV16 serology and risk of squamous cell carcinoma of the head and neck (SCCHN), we genotyped two polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Head and Neck Neoplasms

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Identifiers

PMID: 22086558
DOI: 10.1002/mc.21838
PMCID: PMC3326219

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