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Article

Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx.

Cancer - 15 Mar 2012

Yu Hongping, Sturgis Erich M, Liu Zhensheng, Wang Li-E, Wei Qingyi, Li Guojun

Abstract excerpt

BACKGROUND: The p53 pathway plays a critical role in maintaining genomic stability and preventing tumor formation. Given the roles of both MDM4 and HPV16 E6 oncoproteins in inhibition of p53 activity, we tested the hypothesis that MDM4 polymorphisms are associated with the risk of HPV16-associated squamous cell carcinoma of head and neck (SCCHN). METHODS: Genotyping was conducted on 3 tagging single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21823114
DOI: 10.1002/cncr.26423
PMCID: PMC3213304

Genes

MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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