Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.

doi:10.1159/000331222

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Article

Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.

Human heredity - 1 Jan 2011

Ciampa Julia, Yeager Meredith, Jacobs Kevin, Thun Michael J, Gapstur Susan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie J, Giovannucci Edward, Willett Walter C, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Hunter David, Hoover Robert, Thomas Gilles, Chanock Stephen, Holmes Chris, Chatterjee Nilanjan

Abstract excerpt

AIMS: We introduce an innovative multilocus test for disease association. It is an extension of an existing score test that gains power over alternative methods by incorporating a parsimonious one-degree-of-freedom model for interaction. We use our method in applications designed to detect interactions that generate hypotheses about the functionality of prostate cancer (PRCA) susceptibility regions. METHODS: Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22086326
DOI: 10.1159/000331222
PMCID: PMC3242702

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JAZF1
SULF2

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