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Article

Detection of disease genes by use of family data. II. Application to nuclear families.

American journal of human genetics - 1 Apr 2000

Tu I P, Balise R R, Whittemore A S

Abstract excerpt

Two likelihood-based score statistics are used to detect association between a disease and a single diallelic polymorphism, on the basis of data from arbitrary types of nuclear families. The first statistic, the nonfounder statistic, extends the transmission/disequilibrium test to accommodate affected and unaffected offspring and missing parental genotypes. The second statistic, the founder statistic, compares...

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Identifiers

PMID: 10739759
DOI: 10.1086/302852
PMCID: PMC1288199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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