Article
Sodium bisulfite induces morphological transformation of cultured Syrian hamster embryo cells but lacks the ability to induce detectable gene mutations, chromosome mutations or DNA damage.
Carcinogenesis - 1 Oct 1990
Tsutsui T, Barrett J C
Abstract excerpt
The ability of sodium bisulfite to induce morphological transformation and mutagenesis of cultured Syrian hamster embryo cells was examined. Treatment of the cells at neutral pH for 15 min with 5-20 mM sodium bisulfite resulted in a dose-dependent increase in cell transformation but no induction of gene mutations measured at two genetic loci. Treatment of the cells for 24 h increased the level of transformation,...
Topics
- Animals
- Benzo(a)pyrene
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromosomes
- Cricetinae
- DNA Damage
- Embryo, Mammalian
- Genes
- Mesocricetus