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Article

Reserpine-induced cell transformation without detectable genetic effects in Syrian hamster embryo cells in culture.

Carcinogenesis - 1 Jan 1994

Tsutsui T, Taguchi S, Hasegawa K, Ide T, Kojima K, Matsumura M, Huff J, Barrett J C

Abstract excerpt

Reserpine, a naturally occurring rauwolfia alkaloid, used mainly as an antihypertensive drug, was examined for its ability to induce cell transformation and genetic effects in Syrian hamster embryo (SHE) cells in culture. Treatment of SHE cells with 2 micrograms/ml of reserpine had no effect on c...

Topics

Aneuploidy
Animals
Carcinogens
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Chromosome Aberrations
Cricetinae
DNA
DNA Damage
Embryo, Mammalian
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesocricetus

Mutation

Reserpine

Sodium-Potassium-Exchanging ATPase

Source

Identifiers

PMID: 8293535
DOI: 10.1093/carcin/15.1.11

Genes

SHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8293535-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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