Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.

Genes & development - 15 Nov 2011

Wright Kevin J, Baye Lisa M, Olivier-Mason Anique, Mukhopadhyay Saikat, Sang Liyun, Kwong Mandy, Wang Weiru, Pretorius Pamela R, Sheffield Val C, Sengupta Piali, Slusarski Diane C, Jackson Peter K

Abstract excerpt

The membrane of the primary cilium is a highly specialized compartment that organizes proteins to achieve spatially ordered signaling. Disrupting ciliary organization leads to diseases called ciliopathies, with phenotypes ranging from retinal degeneration and cystic kidneys to neural tube defects. How proteins are selectively transported to and organized in the primary cilium remains unclear. Using a proteomic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to GTP Phosphohydrolases

Share to Kinesins

Share to Monomeric GTP-Binding Proteins

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22085962
DOI: 10.1101/gad.173443.111
PMCID: PMC3222901

Genes

ARL3
NPHP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.PMID 22085962Read ↗

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein CompositionSemantic proximity Read ↗

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architectureSemantic proximity Read ↗

Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.Semantic proximity Read ↗

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.Semantic proximity Read ↗

Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.Semantic proximity Read ↗

The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.Semantic proximity Read ↗

UNC119 is required for G protein trafficking in sensory neurons.Semantic proximity Read ↗

Multiple Ciliary Localization Signals Control INPP5E Ciliary TargetingSemantic proximity Read ↗

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexesSemantic proximity Read ↗

Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment.Semantic proximity Read ↗

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119Semantic proximity Read ↗

Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.