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Article

UNC119 is required for G protein trafficking in sensory neurons.

Nature neuroscience - 5 Jun 2011

Zhang Houbin, Constantine Ryan, Vorobiev Sergey, Chen Yang, Seetharaman Jayaraman, Huang Yuanpeng Janet, Xiao Rong, Montelione Gaetano T, Gerstner Cecilia D, Davis M Wayne, Inana George, Whitby Frank G, Jorgensen Erik M, Hill Christopher P, Tong Liang, Baehr Wolfgang

Abstract excerpt

UNC119 is widely expressed among vertebrates and other phyla. We found that UNC119 recognized the acylated N terminus of the rod photoreceptor transducin α (Tα) subunit and Caenorhabditis elegans G proteins ODR-3 and GPA-13. The crystal structure of human UNC119 at 1.95-Å resolution revealed an immunoglobulin-like β-sandwich fold. Pulldowns and isothermal titration calorimetry revealed a tight interaction between...

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Identifiers

PMID: 21642972
DOI: 10.1038/nn.2835
PMCID: PMC3178889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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