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FAS-1377 G/A (rs2234767) polymorphism and cancer susceptibility: a meta-analysis of 17,858 cases and 24,311 controls.

PloS one - 1 Jan 2013

Zhong-Xing Zhou, Yuan-Yuan Mi, Hai Zhen Ma, Jian-Gang Zou, Li-Feng Zhang

Abstract excerpt

BACKGROUND AND OBJECTIVES: Disruption of apoptosis has been implicated in carcinogenesis. Specifically, various single-nucleotide polymorphisms (SNPs) in apoptotic genes, such as FAS-1377 G/A SNP, have been associated with cancer risk. FAS-1377 G/A SNP has been shown to alter FAS gene promoter transcriptional activity. Down-regulation of FAS and cell death resistance is key to many cancers, but an association...

Topics

Alleles
Female
Gene-Environment Interaction
Genotype
Humans
Male
Neoplasms
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
PubMed
Risk Factors

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Transcription, Genetic

fas Receptor

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Identifiers

PMID: 24014103
DOI: 10.1371/journal.pone.0073700
PMCID: PMC3754923

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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