Article
Construction of regulatory networks using expression time-series data of a genotyped population.
Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2011
Yeung Ka Yee, Dombek Kenneth M, Lo Kenneth, Mittler John E, Zhu Jun, Schadt Eric E, Bumgarner Roger E, Raftery Adrian E
Abstract excerpt
The inference of regulatory and biochemical networks from large-scale genomics data is a basic problem in molecular biology. The goal is to generate testable hypotheses of gene-to-gene influences and subsequently to design bench experiments to confirm these network predictions. Coexpression of genes in large-scale gene-expression data implies coregulation and potential gene-gene interactions, but provide little...
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