Article
Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification.
Proceedings of the National Academy of Sciences of the United States of America - 19 Sept 2006
Lee Su-In, Pe'er Dana, Dudley Aimée M, Church George M, Koller Daphne
Abstract excerpt
Sequence polymorphisms affect gene expression by perturbing the complex network of regulatory interactions. We propose a probabilistic method, called Geronemo, which directly aims to identify the mechanism by which genetic changes perturb the regulatory network. Geronemo automatically constructs a set of coregulated genes (modules), whose regulation can involve both sequence variations and expression of...
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