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[High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Nov 2011

Fukushima Yoshiyuki, Yanaka Shoko, Murakami Kazumi, Abe Yukiko, Koshizaka Takuya, Hara Hirotaka, Samejima Chihiro, Kishi Yoshiro, Kaneda Makoto, Yoshino Takayuki

Abstract excerpt

Clinical studies overseas using the therapeutic anti-EGFR monoclonal antibodies, cetuximab or panitumumab against metastatic colorectal cancer(mCRC), have revealed KRAS mutations as a negative predictive marker of response. Accordingly, the Ministry of Health, Labour and Welfare in Japan approved medical reimbursement of the KRAS mutation test in April 2010. Anti-EGFR monoclonal antibody therapies are now used as...

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PMID: 22083191

Genes

KRAS
EGFR

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[High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer].PMID 22083191Read ↗

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