Article
A novel approach to detect KRAS/BRAF mutation for colon cancer: Highly sensitive simultaneous detection of mutations and simple pre-treatment without DNA extraction.
International journal of oncology - 1 Jul 2015
Suzuki Shun-Ichi, Matsusaka Satoshi, Hirai Mitsuharu, Shibata Harumi, Takagi Koichi, Mizunuma Nobuyuki, Hatake Kiyohiko
Abstract excerpt
It has been reported that colon cancer patients with KRAS and BRAF mutations that lie downstream of epidermal growth factor receptor (EGFR) acquire resistance against therapy with anti‑EGFR antibodies, cetuximab and panitumumab. On the other hand, some reports say KRAS codon 13 mutation (p.G13D) has lower resistance against anti-EGFR antibodies, thus there is a substantial need for detection of specific KRAS...
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