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Article

Role of Hedgehog Signaling in Ovarian Cancer

1 Dec 2008

Abstract excerpt

PURPOSE: In humans, several distinctive cancers result from mutations that aberrantly activate hedgehog (HH) signal transduction. Here, we investigate the role of HH signaling in ovarian cancer. EXPERIMENTAL DESIGN: We assessed the expression of different components of hedghehog pathway in primary tumor samples and cell lines. We used specific hedghehog pathway blocker to study the effect on clonal growth and...

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PMID: 19047091
DOI: 10.1158/1078-0432.ccr-08-1414

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