Article
A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations.
Human molecular genetics - 15 Feb 2012
Bossini-Castillo Lara, Martin Jose-Ezequiel, Broen Jasper, Gorlova Olga, Simeón Carmen P, Beretta Lorenzo, Vonk Madelon C, Callejas Jose Luis, Castellví Ivan, Carreira Patricia, García-Hernández Francisco José, Fernández Castro Mónica, Coenen Marieke J H, Riemekasten Gabriela, Witte Torsten, Hunzelmann Nicolas, Kreuter Alexander, Distler Jörg H W, Koeleman Bobby P, Voskuyl Alexandre E, Schuerwegh Annemie J, Palm Øyvind, Hesselstrand Roger, Nordin Annika, Airó Paolo, Lunardi Claudio, Scorza Raffaella, Shiels Paul, van Laar Jacob M, Herrick Ariane, Worthington Jane, Denton Christopher, Tan Filemon K, Arnett Frank C, Agarwal Sandeep K, Assassi Shervin, Fonseca Carmen, Mayes Maureen D, Radstake Timothy R D J, Martin Javier
Abstract excerpt
A single-nucleotide polymorphism (SNP) at the IL12RB2 locus showed a suggestive association signal in a previously published genome-wide association study (GWAS) in systemic sclerosis (SSc). Aiming to reveal the possible implication of the IL12RB2 gene in SSc, we conducted a follow-up study of this locus in different Caucasian cohorts. We analyzed 10 GWAS-genotyped SNPs in the IL12RB2 region (2309 SSc patients...
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