Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.

doi:10.1371/journal.pgen.1002091

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Article

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.

PLoS genetics - 1 Jul 2011

Allanore Yannick, Saad Mohamad, Dieudé Philippe, Avouac Jérôme, Distler Jorg H W, Amouyel Philippe, Matucci-Cerinic Marco, Riemekasten Gabriella, Airo Paolo, Melchers Inga, Hachulla Eric, Cusi Daniele, Wichmann H-Erich, Wipff Julien, Lambert Jean-Charles, Hunzelmann Nicolas, Tiev Kiet, Caramaschi Paola, Diot Elisabeth, Kowal-Bielecka Otylia, Valentini Gabriele, Mouthon Luc, Czirják László, Damjanov Nemanja, Salvi Erika, Conti Costanza, Müller Martina, Müller-Ladner Ulf, Riccieri Valeria, Ruiz Barbara, Cracowski Jean-Luc, Letenneur Luc, Dupuy Anne Marie, Meyer Oliver, Kahan André, Munnich Arnold, Boileau Catherine, Martinez Maria

Abstract excerpt

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis. We have designed a two-stage genome-wide association study of SSc using case-control samples from France, Italy, Germany, and Northern Europe. The initial...

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PMID: 21750679
DOI: 10.1371/journal.pgen.1002091
PMCID: PMC3131285

Genes

TNIP1
RHOB

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