Article
Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population.
The Journal of investigative dermatology - 1 May 2021
Pu Weilin, Wu Wenyu, Liu Qingmei, Ma Yanyun, Tu Wenzhen, Zuo Xianbo, Guo Gang, Jiang Shuai, Zhao Yinhuan, Zuo Xiaoxia, Wang Qingwen, Yang Li, Xiao Rong, Chu Haiyan, Wang Lei, Sun Liangdan, Cui Jimin, Yu Ling, Li Huiyun, Li Yisha, Shi Yaqian, Zhang Jiaqian, Zhang Haishun, Liang Minrui, Chen Dongdong, Ding Yue, Chen Xiangxiang, Chen Yuanyuan, Zhang Rui, Zhao Han, Li Yuan, Qi Qing, Bai Peng, Zhao Liang, Reveille John D, Mayes Maureen D, Jin Li, Lee Eun Bong, Zhang Xuejun, Xu Jinhua, Zhang Zheng, Zhou Xiaodong, Zou Hejian, Wang Jiucun
Abstract excerpt
Genetic factors play a key role in the pathogenesis of autoimmune diseases, whereas the disease-causing variants remain largely unknown. Herein, we performed an exome-wide association study of systemic sclerosis in a Han Chinese population. In the discovery stage, 527 patients with systemic sclerosis and 5,024 controls were recruited and genotyped. In the validation study, an independent sample set of 479...
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