Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network.

PloS one - 1 Jan 2017

Gursky Vitaly V, Kozlov Konstantin N, Kulakovskiy Ivan V, Zubair Asif, Marjoram Paul, Lawrie David S, Nuzhdin Sergey V, Samsonova Maria G

Abstract excerpt

Annotating the genotype-phenotype relationship, and developing a proper quantitative description of the relationship, requires understanding the impact of natural genomic variation on gene expression. We apply a sequence-level model of gap gene expression in the early development of Drosophila to analyze single nucleotide polymorphisms (SNPs) in a panel of natural sequenced D. melanogaster lines. Using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28898266
DOI: 10.1371/journal.pone.0184657
PMCID: PMC5595321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translating natural genetic variation to gene expression in a computational model of the Drosophila gap gene regulatory network.PMID 28898266Read ↗

Model-based analysis of polymorphisms in an enhancer reveals cis-regulatory mechanismsSemantic proximity Read ↗

In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure.Semantic proximity Read ↗

Sequence-based model of gap gene regulatory network.Semantic proximity Read ↗

Evolutionary origins of transcription factor binding site clusters.Semantic proximity Read ↗

Modularity and interactions in the genetics of gene expression.Semantic proximity Read ↗

Using network component analysis to dissect regulatory networks mediated by transcription factors in yeast.Semantic proximity Read ↗

Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions.Semantic proximity Read ↗

A quantitative validated model reveals two phases of transcriptional regulation for the gap gene giant in Drosophila.Semantic proximity Read ↗

Cis-regulatory variation is typically polyallelic in Drosophila.Semantic proximity Read ↗

The architecture of an empirical genotype-phenotype map.Semantic proximity Read ↗

The genetic landscape of a physical interaction.Semantic proximity Read ↗

Identifying genetic modulators of the connectivity between transcription factors and their transcriptional targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.