Article
In silico evolution of the Drosophila gap gene regulatory sequence under elevated mutational pressure.
BMC evolutionary biology - 7 Feb 2017
Chertkova Aleksandra A, Schiffman Joshua S, Nuzhdin Sergey V, Kozlov Konstantin N, Samsonova Maria G, Gursky Vitaly V
Abstract excerpt
BACKGROUND: Cis-regulatory sequences are often composed of many low-affinity transcription factor binding sites (TFBSs). Determining the evolutionary and functional importance of regulatory sequence composition is impeded without a detailed knowledge of the genotype-phenotype map. RESULTS: We simulate the evolution of regulatory sequences involved in Drosophila melanogaster embryo segmentation during early...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.