Article
Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.
The international journal of neuropsychopharmacology - 1 Oct 2012
O'Tuathaigh Colm M P, Clarke Gerard, Walsh Jeremy, Desbonnet Lieve, Petit Emilie, O'Leary Claire, Tighe Orna, Clarke Niamh, Karayiorgou Maria, Gogos Joseph A, Dinan Ted G, Cryan John F, Waddington John L
Abstract excerpt
Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of dopamine and disturbance in dopamine function is proposed to be central to the pathogenesis of schizophrenia. Clinical epidemiological studies have indicated cannabis use to confer a 2-fold increase in risk for subsequent onset of psychosis, with adolescent-onset use conveying even higher risk. There is evidence that a high activity...
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