Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence.

The international journal of neuropsychopharmacology - 1 Feb 2013

Long Leonora E, Chesworth Rose, Huang Xu-Feng, McGregor Iain S, Arnold Jonathon C, Karl Tim

Abstract excerpt

Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to the development of psychosis-like symptoms after cannabis use. To test whether the schizophrenia candidate gene neuregulin 1 (NRG1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Exploratory Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Motor Activity

Share to Neuregulin-1

Share to Recurrence

Share to Reflex, Startle

Share to Social Behavior

Source

Identifiers

PMID: 22226049
DOI: 10.1017/S1461145711001854

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence.PMID 22226049Read ↗

Heterozygous neuregulin 1 mice are more sensitive to the behavioural effects of Delta9-tetrahydrocannabinol.Semantic proximity Read ↗

Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice.Semantic proximity Read ↗

A follow-up study: acute behavioural effects of Delta(9)-THC in female heterozygous neuregulin 1 transmembrane domain mutant mice.Semantic proximity Read ↗

Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function.Semantic proximity Read ↗

The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids.Semantic proximity Read ↗

A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice.Semantic proximity Read ↗

Cannabidiol (CBD) does not reduce cocaine reward or self-administration in a mouse model of schizophrenia genetic susceptibility.Semantic proximity Read ↗

Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.Semantic proximity Read ↗

Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.Semantic proximity Read ↗

Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia.Semantic proximity Read ↗

Cannabidiol, but Not Δ9-Tetrahydrocannabinol, Has Strain- and Genotype-Specific Effects in Models of Psychosis.Semantic proximity Read ↗

Association of Cannabis Use during Adolescence, Prefrontal CB1 Receptor Signaling, and SchizophreniaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.