Article
Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2010
O'Tuathaigh Colm M P, Hryniewiecka Magdalena, Behan Aine, Tighe Orna, Coughlan Catherine, Desbonnet Lieve, Cannon Mary, Karayiorgou Maria, Gogos Joseph A, Cotter David R, Waddington John L
Abstract excerpt
Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high-low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20 days) during either...
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