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Article

Assessing predicted HIV-1 replicative capacity in a clinical setting.

PLoS pathogens - 1 Nov 2011

Kouyos Roger D, von Wyl Viktor, Hinkley Trevor, Petropoulos Christos J, Haddad Mojgan, Whitcomb Jeannette M, Böni Jürg, Yerly Sabine, Cellerai Cristina, Klimkait Thomas, Günthard Huldrych F, Bonhoeffer Sebastian

Abstract excerpt

HIV-1 replicative capacity (RC) provides a measure of within-host fitness and is determined in the context of phenotypic drug resistance testing. However it is unclear how these in-vitro measurements relate to in-vivo processes. Here we assess RCs in a clinical setting by combining a previously published machine-learning tool, which predicts RC values from partial pol sequences with genotypic and clinical data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22072960
DOI: 10.1371/journal.ppat.1002321
PMCID: PMC3207887

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