Article
Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics.
American journal of hematology - 1 Jan 2012
Ghanem Hady, Tank Niki, Tabbara Imad A
Abstract excerpt
Acute myelogenous leukemia (AML) is a genetically heterogeneous disease in which somatic mutations, that disturb cellular growth, proliferation, and differentiation, accumulate in hematopoietic progenitor cells. Cytogenetic findings, at diagnosis, have been proven to be one of the most important prognostic indicators in AML. About half of the patients with AML are found to have "normal" cytogenetic analysis by...
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