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Article

GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells.

Glia - 1 Feb 2012

Kuegler Philipp B, Baumann Bettina A, Zimmer Bastian, Keller Sascha, Marx Andreas, Kadereit Suzanne, Leist Marcel

Abstract excerpt

The directed generation of pure astrocyte cultures from pluripotent stem cells has proven difficult. Generation of defined pluripotent-stem-cell derived astrocytes would allow new approaches to the investigation of plasticity and heterogeneity of astrocytes. We here describe a two-step differentiation scheme resulting in the generation of murine embryonic stem cell (mESC) derived astrocytes (MEDA), as...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22072312
DOI: 10.1002/glia.21257

Genes

GFAP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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