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Article

Association between cytochrome P450 2C19 polymorphism and clinical outcomes in clopidogrel-treated Uygur population with acute coronary syndrome: a retrospective study.

BMC cardiovascular disorders - 12 Aug 2021

Yu Luhai, Wang Tingting, Bai Huidong, Zhu Weijiang, Li Yanju, Wu Jianhua, Liu Wenli, Sun Li, Yu Aiping, Li Hongjian

Abstract excerpt

BACKGROUND: Acute coronary syndrome (ACS) has become a vital disease with high mortality in the Uygur populations. Clopidogrel plays an important role in reducing the risk of recurrent cardiovascular events after ACS; however, it is a prodrug that requires biotransformation by cytochrome P450 (CYP450). OBJECTIVES: To determine the effect of genetic polymorphisms in CYP2C19*2, *3, and *17, and along with clinical,...

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Identifiers

PMID: 34384383
DOI: 10.1186/s12872-021-02201-4
PMCID: PMC8359105

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