Article
Separation of stem cell maintenance and transposon silencing functions of Piwi protein.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011
Klenov Mikhail S, Sokolova Olesya A, Yakushev Evgeny Y, Stolyarenko Anastasia D, Mikhaleva Elena A, Lavrov Sergey A, Gvozdev Vladimir A
Abstract excerpt
Piwi-interacting RNAs (piRNAs) and Piwi proteins have the evolutionarily conserved function of silencing of repetitive genetic elements in germ lines. The founder of the Piwi subfamily, Drosophila nuclear Piwi protein, was also shown to be required for the maintenance of germ-line stem cells (GSCs). Hence, null mutant piwi females exhibit two types of abnormalities, overexpression of transposons and severely...
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