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Article

Reversal of rectification and alteration of selectivity and pharmacology in a mammalian Kv1.1 potassium channel by deletion of domains S1 to S4.

The Journal of physiology - 15 Nov 1994

Tytgat J, Vereecke J, Carmeliet E

Abstract excerpt

1. A possible relation between the family of inwardly rectifying K+ channels and the Shaker superfamily of K+ channels was investigated using a deletion mutant (DelS1-S4) of a delayed rectifier Kv1.1 (RCK1) K+ channel. 2. The mutant DelS1-S4 was made by eliminating the sequence coding for transmembrane domains S1 to S4 of the Kv1.1 K+ channel, and re-ligating the sequence coding for the cytoplasmic amino terminus...

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Identifiers

PMID: 7853250
DOI: 10.1113/jphysiol.1994.sp020414
PMCID: PMC1155861

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