Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.

doi:10.1007/s00702-011-0732-4

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Article

Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Apr 2012

Kölsch Heike, Lehmann Donald J, Ibrahim-Verbaas Carla A, Combarros Onofre, van Duijn Cornelia M, Hammond Naomi, Belbin Olivia, Cortina-Borja Mario, Lehmann Michael G, Aulchenko Yurii S, Schuur Maaike, Breteler Monique, Wilcock Gordon K, Brown Kristelle, Kehoe Patrick G, Barber Rachel, Coto Eliecer, Alvarez Victoria, Deloukas Panos, Mateo Ignacio, Maier Wolfgang, Morgan Kevin, Warden Donald R, Smith A David, Heun Reinhard

Abstract excerpt

Altered glucose metabolism has been described in Alzheimer's disease (AD). We re-investigated the interaction of the insulin (INS) and the peroxisome proliferator-activated receptor alpha (PPARA) genes in AD risk in the Epistasis Project, including 1,757 AD cases and 6,294 controls. Allele frequencies of both SNPs (PPARA L162V, INS intron 0 A/T) differed between Northern Europeans and Northern Spanish. The PPARA...

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PMID: 22065208
DOI: 10.1007/s00702-011-0732-4

Genes

INS
PPARA

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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